Wilson LC, Peebles KC, Hoye NA, Manning P, Sheat C, Williams MJA, Wilkins GT, Wilson GA, Baldi JC. Resting heart rate variability and exercise capacity in Type 1 diabetes. Physiol Rep 2017;5:e13248

Wilson GA, Wilson LC, Lamberts RR, Majeed K, Lal S, Wilkins GT, Baldi JC. ?-Adrenergic Responsiveness in the Type 2 Diabetic Heart: Effects on Cardiac Reserve. Med Sci Sports Exerc. 2017 ;49(5):907-914

Munasinghe PE, Katare R. Reply to the letter to editor "Autophagy may be impelled by collected fatty acids in type 2 diabetic myocardial cells". Int J Cardiol. 2017;229:4.

Dixit P, Donnelly H, Edamatsu M, Galvin I, Bunton R, Katare R. Progenitor cells from atria, ventricle and peripheral blood of the same patients exhibit functional differences associated with cardiac repair. Int J Cardiol. 2017;228:412-421.

Jones PP, Guo W, Chen SRW. Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca2. J Gen Physiol 2017;149(9):867-875

Gonano LA, Jones PP. FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: Insights from new functional and structural knowledge. Channels 2017;11(5):415-425

Satthenapalli VR, Lamberts RR, Katare RG. Concise Review: Challenges in Regenerating the Diabetic Heart: A Comprehensive Review. Stem Cells 2017;35(9):2009-2026

Rawal S, Munasinghe PE, Nagesh PT, Lew JKS, Jones GT, Williams MJA, Davis P, Bunton D, Galvin IF, Manning P, Lamberts RR, Katare R. Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type 2 diabetic human and mouse heart. Clin Sci 2017;131(9):847-863.

Ram TP, Fomison-Nurse I, Gandhi S, Coffey S, Saxena P, Galvin I, Bunton R, Williams MJ, Lamberts RR, Katare R. The diagnostic sensitivity of circulating cardio-enriched microRNAs is increased after normalization of high-density lipoprotein levels. Int J Cardiol. 2017;236:498-500.

Lew JK, Pearson JT, Schwenke DO, Katare R. Exercise mediated protection of diabetic heart through modulation of microRNA mediated molecular pathways. Cardiovasc Diabetol. 2017;16(1):10

Rawal S, Munasinghe PE, Shindikar A, Paulin J, Cameron V, Manning P, Williams MJ, Jones GT, Bunton R, Galvin I, Katare R. Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy. Cardiovasc Res. 2017;113(1):90-101

Bussey CT, Lamberts RR. Effect of type 2 diabetes, surgical incision, and volatile anesthesia on hemodynamics in the rat. Physiol Rep 2017;5(14):e133252

Cook RF, Bussey CT, Mellor KM, Cragg PA, Lamberts RR. ?1 -Adrenoceptor, but not ?2 -adrenoceptor, subtype regulates heart rate in type 2 diabetic rats in vivo. Exp Physiol 2017;102(8):911-923

Aitken-Buck HM, Lamberts RR. To the heart of activation heat. J Physiol 2017 15;595(14):4577-4578


Xiao Z, Guo W, Sun B, Hunt DJ, Wei J, Liu Y, Wang Y, Wang R, Jones PP, Back TG, Chen SR. Enhanced Cytosolic Ca2+ Activation Underlies a Common Defect of Central Domain Cardiac Ryanodine Receptor Mutations Linked to Arrhythmias. J Biol Chem. 2016;291(47):24528-24537.

Waddell HMM, Zhang JZ, Hoeksema KJ, McLachlan JJ, McLay JC, Jones PP. Oxidation of RyR2 Has a Biphasic Effect on the Threshold for Store Overload-Induced Calcium Release. Biophys J. 2016;110(11):2386-2396.

Munasinghe PE, Riu F, Dixit P, Edamatsu M, Saxena P, Hamer NS, Galvin IF, Bunton RW, Lequeux S, Jones G, Lamberts RR, Emanueli C, Madeddu P, Katare R. Data supporting the activation of autophagy genes in the diabetic heart. Data Brief. 2015;5:269-75.

Munasinghe PE, Riu F, Dixit P, Edamatsu M, Saxena P, Hamer NS, Galvin IF, Bunton RW, Lequeux S, Jones G, Lamberts RR, Emanueli C, Madeddu P, Katare R. Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway. Int J Cardiol. 2016;202:13-20.

Baldi JC, Wilson GA, Wilson LC, Wilkins GT, Lamberts RR. The Type 2 Diabetic Heart: Its Role in Exercise Intolerance and the Challenge to Find Effective Exercise Interventions. Sports Med. 2016;46(11):1605-1617

Diong C, Jones PP, Tsuchimochi H, Gray EA, Hughes G, Inagaki T, Bussey CT, Fujii Y, Umetani K, Shirai M, Schwenke DO. Sympathetic hyper-excitation in obesity and pulmonary hypertension: physiological relevance to the 'obesity paradox'. Int J Obes. 2016;40(6):938-46.

Katare R, Rawal S, Munasinghe PE, Tsuchimochi H, Inagaki T, Fujii Y, Dixit P, Umetani K, Kangawa K, Shirai M, Schwenke DO. Ghrelin Promotes Functional Angiogenesis in a Mouse Model of Critical Limb Ischemia Through Activation of Proangiogenic MicroRNAs. Endocrinology. 2016;157(2):432-45.

Rawal S, Ram TP, Coffey S, Williams MJA, Saxena P, Bunton RW, Galvin IF, Katare R. Differential expression pattern of cardiovascular microRNAs in the human type-2 diabetic heart with normal ejection fraction. Int J Cardiol 2016;202:40-3.

Devlin G, Hamer A, Troughton R, Gamble GD, Matsis P, Williams MJA, Elliott JM, Mann S, Richards AM, French JK, White HD, Ellis CJ. Management of non ST-elevation acute coronary syndrome patients in New Zealand: a longitudinal analysis. Results from the New Zealand acute coronary syndrome (ACS) audits of 2002, 2007 and 2012. NZ Med J 2016;129:10-16.

Coffey S, Cox B, Williams MJA. Changing causes of heart valve disease mortality in New Zealand from 1988 to 2007. NZ Med J 2016;129:56-65.

Williams MJA, Harding SA, Devlin G, Nunn C, El-Jack S, Scott T, Lee M, Kerr AJ. National variation in coronary angiography rates and timing after acute coronary syndrome in New Zealand (ANZACS-QI 6). NZ Med J 2016;129:66-78.

Mandic S, Hodge C, Stevens E, Hodge C, Brown C, Walker R, Body D, Barclay L, Nye ER, Williams MJA. Long-term effects of cardiac rehabilitation in elderly individuals with stable coronary artery disease. Disabil Rehabil 2016;38:837-43.

Barr P, Smyth D, Harding S, El-Jack S, Williams MJA, Devlin G, Stewart J, Flynn C, Lee M, Kerr AJ. Variation in arterial access for invasive coronary angiography in New Zealand: a national analysis (ANZACS-QI 5). Heart Lung Circ 2016;25:451-8

Thomas KN, Cotter JD, Williams MJA, van Rij AM. Diagnosis, incidence and clinical implications of perioperative myocardial injury in vascular surgery. Vasc Endovascular Surg 2016;50:247-55.

Thomas KN, Cotter JD, Williams MJA, van Rij AM. Repeated episodes of remote ischaemic preconditioning for the prevention of myocardial injury in vascular surgery. Vasc Endovascular Surg 2016;50:140-6.

Jones GT, Phillips LV, Williams MJA, van Rij AM, Kabir TD. Two C-C family chemokines, Eotaxin and RANTES, are novel independent plasma biomarkers for abdominal aortic aneurysm. J Am Heart Assoc 2016;5:e002993.

Nioi P, Thorleifsson G, Sigurdsson A, ….., Williams MJA, van Rij AM, Jones GT et al. A rare intronic deletion that disrupts ASGR1 function lowers non-HDL cholesterol and protects against coronary artery disease. N Eng J Med 2016;374:2131-41.

Jones GT, Hill BG, Curtis N, Kabir TD, Wong LE, Tilyard MW, Williams MJA, van Rij AM. Comparison of three targeted abdominal aortic aneurysm screening approaches based on cardiovascular risk; identification both male and female subgroups with significantly elevated prevalence. Br J Surg 2016;103:1139-46.

Kerr AJ, Williams MJA, Harding S, White H, Doughty RN, Nunn C, Grey C, Lee M, Flynn C, Rhodes M, Sutherland K, Jackson RT, Stewart RAH on behalf of the ANZACS-QI investigators. The All New Zealand Acute Coronary Syndrome Quality Improvement Programme: Implementation, Methodology and Cohorts (ANZACS-QI 9). NZ Med J 2016;129: 23-36.


Zhang JZ, Waddell HM, Jones PP. Regulation of RyR2 by Sarcoplasmic Reticulum Ca2+. Clin Exp Pharmacol Physiol. doi: 10.1111/1440-1681.12364. (in press)

Mi T, Xiao Z, Guo W, Tang Y, Hiess F, Xiao J, Wang Y, Zhang JZ, Zhang L, Wang R, Jones PP, Chen SR. Role of Cysteine-3602 in the Function and Regulation of the Cardiac Ryanodine Receptor. Biochem J. (in press)

Liu Y, Sun B, Xiao Z, Wang R, Guo W, Zhang JZ, Mi T, Wang Y, Jones PP, Petegem FV, Chen SR. Roles of the NH2-terminal Domains of Cardiac Ryanodine Receptor in Ca2+ Release Activation and Termination. J Biol Chem. pii: jbc.M114.618827. (in press)

Purvis N, Bahn H and Katare R. The Role of MicroRNAs in Cardiac Stem Cells. Stem Cells Int 2015:950312. doi - 10.1155/2015/194894

Dixit P and Katare R. Challenges in identifying the best source of stem cells for cardiac regeneration therapy. Stem Cell Res Ther. 2015 (In press)

Ascione R, Rowlinson J, Avolio E, Katare R, Meloni M, Spencer H, Mangialardi G, Krankel N, Spinetti G, Emanueli C, Madeddu P, Norris C. Migration towards SDF-1 selects angiogenin-expressing bone marrow monocytes endowed with cardiac reparative activity in patients with previous myocardial infarction. Stem Cell Res Ther. 2015 (In press)

Munasinghe PE, Riu F, Dixit P, Midori E, Saxena P, Hamer NSJ, Galvin IF, Bunton RW, Lequeux S, Jones G, Lamberts RR, Emanueli C, Madeddu P, Katare R. Diabetes increases autophagy in the human heart through promotion of Beclin-1

Thaung HPA, Baldi JC, Wang HY, Cook RF, Hughes G, Bussey CT, Sheard PS, Jones PP, Bahn A, Schwenke DO, Lamberts RR. Increased cardiac SNA and reduced cardiac functional responsiveness in Zucker Diabetic Fatty rats. Diabetes 2015. (in press)

Green S, Egana M, Baldi JC, Lamberts RR, Regensteiner JG. Cardiovascular control during exercise in type 2 diabetes mellitus. Journal of Diabetes Research 2015. (in press)

Thaung HPA, Yao Y, Bussey CT, Hughes G, Jones PP, Bahn A, Sammut IA, Lamberts RR. Chronic bilateral renal denervation reduces cardiac hypertrophic remodeling but not b-adrenergic responsiveness in the hypertensive type 1 diabetic rat. Experimental Physiology 2015. (in press).

Bussey CT, Hughes G, Saxena P, Galvin IF, Bunton RW, Noye MK, Coffey S, Williams MJA, Baldi JC, Jones PP, Lamberts RR. Increased SERCA2a/phospholamban ratio in human atrial, but not ventricular, tissue in type-2 diabetes with preserved ejection fraction. International Journal of Cardiology 193:53-5 (2015).

Bussey CT, Hughes G, Saxena P, Galvin IF, Bunton RW, Noye MK, Coffey S, Williams MJ, Baldi JC, Jones PP, Lamberts RR. Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. Int J Cardiol. 2015;193:53-55.

Nagai, H., Kuwahira, I., Schwenke, D.O., Tsuchimochi, H., Nara, A., Ogura, S., Inagaki, T., Fujii, Y., Yamaguchi, R., Wingenfeld, L., Umetani, K., Shimosawa, T., Yoshida, K., Pearson, J.T., Uemura, K., Shirai, M (2015). Pulmonary macrophages attenuate hypoxic pulmonary vasoconstriction via ?3AR/iNOS pathway in rats exposed to chronic intermittent hypoxia. PLOS ONE. In Press.

Ashley, Z., Schwenke, D.O., Cragg, P.A (2015). Hyperventilation in normoxia following myocardial infarction in rats: A shift in the set point of the hypoxic ventilatory response. Acta Physiol, In Press.

Sonobe, T., Tsuchimochi, H., Schwenke, D.O., Pearson, J.T., Shirai, M (2015). Treadmill running improves hindlimb arteriolar endothelial function in type 1 diabetic mice as visualized by X-ray microangiography. Cardiovasc Diabetol. In Press.

Majeed KM, Hamer AW, White SC, Pegg TJ, Wilkins GT, Williams SM, Chen YH, Williams MJA. Screening for abdominal aortic aneurysm in patients referred for transthoracic echocardiography. Intern Med J 2015;45:32-9.

Walters DL, Webster M, Pasupati S, Walton A, Muller D, Stewart J, Williams M, MacIsasc A, Scalia G, Wilson M, Gamel AE, Clarke A, Bennetts J, Bannon P. Position statement for the operator and institutional requirements for a transcatheter aortic valve implanation (TAVI) program. Heart Lung Circ 2015;24:219-23.

Ellis C, Hammett C, Ranasinghe I, Briffa T, Devlin G, Elliott J, Aliprandi-Costa B, Astley C, Redfern J, Howell T, Carr B, Lintern K, Lefkovitz J, Bloomer S, Matsis P, Hamer A, Williams M, Troughton R, Horsfall M, Hyun K, Gamble G, White H, French J, Brieger D, Chew D. For the Bi-National Acute Coronary Syndromes (ACS) ‘SNAPSHOT’ Audit Group. A comparison of the management of acute coronary syndrome patients in Australasia and New Zealand: results from the Bi-National SNAPSHOT 2012 Audit. Internal Medicine Journal 45:497-509 (2015).

Mandic S, Body D, Barclay L, Walker R, Nye ER, Grace SL, Williams MJA. Community-based cardiac rehabilitation maintenance programs: use and effects. Heart Lung and Circulation 24:710-18 (2015).

Sharma M, von Zychlinski A, Porteous C, Jones GT, Williams MJA, McCormick SPA. Lipoprotein(a) upregulates ABCA1 in liver cells via scavenger receptor-B1 through its oxidized phospholipids. Journal of Lipid Research 56:1318-28 (2015).

Coffey S, Williams MJA, Phillips LV, Jones GT. Circulating microRNA profiling needs further refinement before clinical use in patients with aortic stenosis. Journal of the American Heart Association 4:e002150 (2015).

Mandic S, Hodge C, Stevens E, Hodge C, Brown C, Walker R, Body D, Barclay L, Nye ER, Williams MJA. Long-term effects of cardiac rehabilitation in elderly individuals with stable coronary artery disease. Disability and Rehabilitation (2015)

Horwood H, Williams MJA, Mandic S. Examining motivations and barriers for attending maintenance community-based cardiac rehabilitation using the Health-Belief model. Heart Lung and Circulation 10:980-7 (2015)

Theodore RF, Broadbent J, Nagin D, Ambler A, Hogan S, Ramrakha S, Cutfield W, Williams MJA, Harrington H, Moffitt TE, Caspi A, Milne B, Poulton R. Childhood to early mid-life systolic blood pressure trajectories: early life predictors, effect modifiers, and adult cardiovascular outcomes. Hypertension 66:1108-15 (2015)


Baldi JC, Dacey MJ, Lee JM, Coast JR. The effect of prior maximal exercise on pulmonary diffusing capacity during a subsequent exercise bout. Int J Sports Med 35(12):982-6. 2014

Francois ME, Baldi JC, Manning PJ, Lucas SE, Hawley JA, Williams MJA, Cotter JD. Exercise snacking before meals: a novel strategy to improve glycaemic control in individuals with insulin resistance. Diabetologia 57(7):1437-45. 2014

Pinto TE, Gusso S, Hofman PL, Derraik JGB, Hornung TS, Cutfield WS, Baldi JC. Systolic and diastolic abnormalities reduce cardiac and aerobic capacity in adolescents with type 2 diabetes. Diabetes Care 37(5):1439-46. 2014

Zhang DM, Chai Y, Erickson JR, Heller Brown J, Bers DM, Lin YF. Modulation of Sarcolemmal ATP-Sensitive Potassium Channels by Nitric Oxide via sGC/PKG/ROS/ERK1/2/CaMKII Signaling in Ventricular Cardiomyocytes. Journal of Physiology. 1;592(Pt 5) 2014

Bell JR, Raaijmakers AJ, Curl CL, Reichelt ME, Harding TW, Bei A, Ng DC, Erickson JR, Vila Petroff M, Harrap SB, Delbridge LM. Cardiac CaMKII? splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart. Int J Cardiol. (2014) 181C:288-296.

Bell JR, Erickson JR, Delbridge LM. Ca(2+) /calmodulin dependent kinase II: a critical mediator in determining reperfusion outcomes in the heart? Clin Exp Pharmacol Physiol. (2014) 41:940-6.

Erickson JR. Mechanisms of CaMKII Activation. Frontiers in Pharmacology Research. (2014) 5:59.

Jian Z, Han H, Zhang T, Puglisi J, Izu LT, Shaw JA, Onofiok E, Erickson JR, Chen YJ, Horvath B, Shimkunas R, Xiao W, Li Y, Pan T, Chan J, Banyasz T, Tardiff JC, Chiamvimonvat N, Bers DM, Lam KS, Chen-Izu Y.Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Sci Signal. 18;7(317):ra27. 2014

Chen W, Wang R, Chen B, Zhong X, Kong H, Bai B, Zhou Q, Xie C, Zhang J, Guo A, Tian X, Jones PP, et al. The Ryanodine Receptor Store Sensing Gate Controls Ca2+ Waves and Ca2+ Triggered Arrhythmias. Nat. Med. 2014; 20(2):184-92

Lamberts RR, Lingam SJ, Wang HY, Bollen IAE, Hughes G, Saxena P, Galvin IF, Bunton RW, Bahn A, Katare R, Baldi JC, Williams MJA, Coffey S, Jones PP. Impaired relaxation despite upregulated calcium-handling proteins in atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology. 13: 72-83, 2014.

Zhang JZ, McLay JC, Jones PP. The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+). Journal of Molecular and Cellular Cardiology, 74:22-31. 2014

Moore A, Shindikar A, Fomison-Nurse I, Riu F, Munasinghe P, Parshu Ram T, Saxena P, Coffey S, Bunton RW, Galvin IF, Williams MJ, Emanueli C, Madeddu P, Katare R. Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1. Cardiovasc Diabetol. 2014; 13(1):44

Rawal S, Manning P, Katare R. Cardiovascular microRNAs: as modulators and diagnostic biomarkers of diabetic heart disease. Cardiovasc Diabetol. 2014; 13(1):44

Katare R, Stroemer P, Hicks C, Stevanato L, Patel S, Corteling R, Miljan E, Vishnubhatla I, Sinden J, Madeddu P. Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia. Arterioscler Thromb Vasc Biol. 2014; 34(2):408-18

Avolio E, Gianfranceschi G, Cesselli D, Caragnano A, Athanasakis E, Katare R, Meloni M, Palma A, Barchiesi A, Vascotto C, Toffoletto B, Mazzega E, Finato N, Aresu G, Livi U, Emanueli C, Scoles G, Beltrami CA, Madeddu P, Beltrami AP. Ex vivo molecular rejuvenation improves the therapeutic activity of senescent human cardiac stem cells in a mouse model of myocardial infarction. Stem Cells 32(9):2373-85. 2014

Gubernator M, Slater SC, Spencer HL, Spiteri I, Sottoriva A, Riu F, Rowlinson J, Avolio E, Katare R, Mangialardi G, Oikawa A, Reni C, Campagnolo P, Spinetti G, Touloumis A, Tavaré S, Prandi F, Pesce M, Hofner M, Klemens V, Emanueli C, Angelini G, Madeddu P. Epigenetic profile of human adventitial progenitor cells correlates with therapeutic outcomes in a mouse model of limb ischemia. Arterioscler Thromb Vasc Biol 35(3):675-88. 2014

CT Bussey, AE de Leeuw, RF Cook, Z Ashley, J Schofield, RR Lamberts. Dual Implantation of a Radio-Telemeter and Vascular Access Port allows repeated conscious hemodynamic and pharmacological measures in lean and obese rats. Laboratory Animals, 48(3), 250-260, 2014.

CT Bussey, AE de Leeuw, RR Lamberts. Increased hemodynamic adrenergic load with isoflurane anesthesia in type 2 diabetic and obese rats in vivo. Cardiovascular Diabetology 13:161. 2014.

Nagai, H. Kuwahira, I. Schwenke, D.O. Tsuchimochi, H. Nara, A. Inagaki, T. Ogura, S. Fujii, Y. Umetani, K. Shimosawa, T. Yoshida, K. Uemura, K. Shirai, M (2014). ß2-adrenergic receptor-dependent attenuation of hypoxic pulmonary vasoconstriction prevents progression of pulmonary arterial hypertension in intermittent hypoxic rats. PLOS ONE. 28;9(10)e110693.

Shirai, M. Tsuchimochi, H., Nagai, H., Gray, E., Pearson, J.T., Sonobe, T., Yoshimoto, M., Inagaki, T., Fujii, Y., Umetani, K., Kuwahira, I., Schwenke, D.O (2014). Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve activity following chronic intermittent hypoxia. Basic Res. Cardiol. 109(5):432.

Du, C-K., Zhan, D-Y., Morimoto, S., Akiyama, T., Schwenke, D.O., Hosoda, H., Kangawa, K., and Shirai, M (2014). Survival benefit of ghrelin in the heart failure due to dilated cardiomyopathy. Pharma Res Per, 2(5), 2014.

Han, Su., Gray, E.A., Gillian, H., Brown, C.H., and Schwenke D.O (2014). Increased sympathetic drive during the onset of hypertension in conscious Cyp1a1-Ren2 rats. Pflügers Archiv: Euro J Physiol. 466(3) 459-466.

Jin C, Phillips LV, Williams MJA, van Rij AM, Jones GT. Plasma heat shock protein 27 is associated with coronary artery disease, abdominal aortic aneurysm and peripheral artery disease. SpringerPlus 2014;3:635.

Kerr, AJ, Williams, MJA. Infective endocarditis: trends in the disease and how we study them. NZ Med J 2014;124.

Coffey, S, Cox, B, Williams, MJA. Lack of progress in valvular heart disease in the pre-TAVR era: increasing deaths and minimal change in mortality rate over the past three decades. Am Heart J 2014:167:562-7.

Coffey, S, Cox, B, Williams, MJA. The prevalence, incidence, progression, and risks of aortic valve sclerosis: a systematic review and meta-analysis. J Am Coll Cardiol 2014.

von Zychlinski A, Williams MJA, McCormick SM, Kleffmann T. Absolute quantification of apolipoproteins and associated proteins on plasma lipoproteins. J Proteomics 2014;106:181-90.

Kader T, Porteous C, Williams MJA, Gieseg S, McCormick SPA. Ribose-cysteine increases glutathione-based antioxidant status and reduces LDL in human lipoprotein(a) mice. Atherosclerosis 2014;237:725-22.


Jones LM, Stoner L, Brown C, Baldi C, McLaren B. Cardiovascular disease among breast cancer survivors: the call for a clinical vascular health toolbox. Breast Cancer Research and Treatment 2013 142:645-53.

Hoye NA, Baldi JC, Putt TL, Schollum JB, Wilkins GT, Walker RJ. Endovascular renal denervation: a novel sympatholytic with relevance to chronic kidney disease. Clinical Kidney Journal 2013, 0:1-8.

Baldi JC, Manning P, Hofman PL, Walker RJ. Comment on TODAY Study Group: Effects of Metformin, Metformin plus Rosiglitazone, and Metformin plus lifestyle on insulin sensitivity and ?-cell function in TODAY. Diabetes Care 2013, e223.

Erickson JR, Pereira L, Wang L, Ferguson A, Dao K, Despa F, Hart GW, Ripplinger CM, Bers DM. Activation of calcium/calmodulin dependent kinase II by O-GlcNAc is induced by diabetic hyperglycemia. Nature. 502:372-6. 2013

Liu Y, Kimlicka L, Hiess F, Tian X, Wang R, Zhang L, Jones PP, van Petegem F, Chen SR. The CPVT-associated RyR2 Mutation G230C Enhances Store Overload-Induced Ca2+ Release and Destabilizes the NH2-terminal domains. Biochem J. 2013; 454(1):123-31

Bai Y, Jones PP, Guo J, Zhong X, Clark RB, Zhou Q, Wang R, Vallmitjana A, Benitez R, Hove-Madsen L, Semeniuk L, Guo A, Song L-S, Duff HJ, Chen SR. Phospholamban Knockout Breaks Arrhythmogenic Ca2+ Waves and Suppresses Catecholaminergic Polymorphic Ventricular Tachycardia in Mice. Circ. Res. 113(9):517-26, 2013

Katare R, Riu F, Rowlinson J, Lewis A, Holden R, Meloni M, Reni C, Wallrapp C, Emanueli C, Madeddu P. Perivascular delivery of encapsulated mesenchymal stem cells improves postischemic angiogenesis via paracrine activation of VEGF-A. Arterioscler Thromb Vasc Biol. 2013; 33(8):1872-80

Katare RG, Madeddu P. Pericytes from human veins for treatment of myocardial ischemia. Trends Cardiovasc Med. 2013; 23(3):66-70.

Katare R, Oikawa A, Cesselli D, Beltrami AP, Avolio E, Muthukrishnan D, Munasinghe PE, Angelini G, Emanueli C, Madeddu P. Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes. Cardiovasc Res. 2013; 97(1):55-65.

Sorrenson, B, Suetani, RJ, Williams, MJA, Bickley, VM, George, PM, Jones, GT, McCormick, SPA. Functional rescue of mutant ABCA1 proteins by sodium 4-phenylbutyrate. J Lipid Res 2013;54:55-62.

Tarr, GP, Williams, MJA, Wilkins, GT, Chen, VHT, Phillips, LV, van Rij, AM, Jones, GT. Intra-individual changes of active matrix metalloproteinase-9 are associated with in-stent restenosis of bare metal stents. Cardiology 2013;124:28-35.

Jones GT, Bown MJ, Gretarsdottir S, Romaine S, Helgadottir A, Yu G, Tromp G, Norman PE, Jin C, Baas AF, Blankensteijn JD, Kullo IJ, Phillip LV, Williams MJA, et al. A sequence variant associated with Sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm. Hum Mol Genet 2013;22:2941-7.

Mandic S, Walker R, Stevens E, Nye ER, Body D, Barclay L, Williams MJA. Estimating exercise capacity from walking tests in elderly patients with stable coronary artery disease. Disabil Rehabil 2013;35:1853-8. doi:10.3109/09638288.2012.759629

Tong, IS, Williams, MJA, Perez, DJ. Nonbacterial thrombotic endocarditis with ST-elevation myocardial infarction treated with percutaneous coronary aspiration thrombectomy. Heart Lung Circ 2013;22:386-9.

Mandic S, Hodge C, Stevens E, Walker R, Nye ER, Body D, Barclay L, Williams MJA. Effects of community-based cardiac rehabilitation on body composition and physical function in individuals with stable coronary artery disease: 1.6 year follow-up. BioMed Res Int 2013, Article ID 903604.

Murrell, CJ, Cotter, JD, Thomas, KN, Lucas, SJE, Williams, MJA, Ainslie, PN. Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: effect of age and 12 week exercise training. AGE 2013;35:905-20.

Chu, JW, Jones, GT, Tarr, GP, Phillips, LV, Wilkins, GT, van Rij, AM, Williams, MJA. Plasma active matrix metalloproteinase 9 and indices of diastolic function in patients with preserved systolic function. Int J Cardiol 2013;167:1242-6.

ST-Elevation Myocardial Infarction Guidelines Group and the New Zealand Branch of the Cardiac Society of Australia and New Zealand. ST-elevation myocardial infarction: New Zealand management guidelines: 2013. NZ Med J 2013;126.

Ellis CJ, Gamble GD, Devlin G, Elliott JM, Hamer A, Williams MJA, Matsis P, Troughton R, Ranasingh I, French J, Brieger D, Chew D, White, HD. The management of acute coronary syndrome patients across New Zealand in 2012: results of a third comprehensive nationwide audit and observations of current care. NZ Med J 2013;126.


Gusso S, Salvador C, Hofman P, Cutfield W, Baldi JC, Taberner A, Nielsen P. Design and construction of an MRI-compatible cycle ergometer for non-invasive cardiac assessments during exercise. Biomedical Engineering Online. Mar 18;11-13, 2012.

Wimer GS, Baldi JC. Limb-specific training affects exercise hyperemia but not sympathetic vasoconstriction. European Journal of Applied Physiology 112:3819-28, 2012.

Carrick-Ranson G, Gamble GD, Whalley GA, Doughty RN, Baldi JC. The larger exercise stroke volume in endurance trained men does not result from increased left ventricular early or late inflow or tissue velocities. Acta Physiologica. 205:520-531, 2012.

Gusso S, Pinto T, Baldi JC, Robinson E, Cutfield WS, Hofman PL. Diastolic function is reduced in type 1 diabetic adolescents in response to exercise: Diabetes Care 35: 2089-94, 2012.

Coffey S, Nadarasa K, Pan A, van der Linden A, Chu J, Schultz M. The increasing incidence of Streptococcus bovis endocarditis and bacteraemia: a case series from 1997 to 2010. International Journal of Cardiology 2012, doi: 10.1016/j.ijcard.2012.06.031

Amadesi S, Reni C, Katare R, Meloni M, Oikawa A, Beltrami AP, Avolio E, Cesselli D, Fortunato O, Spinetti G, Ascione R, Cangiano E, Valgimigli M, Hunt SP, Emanueli C, Madeddu P. Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects. Circulation. 2012; 125(14):1774-86, S1-19.

Mechanical ventilation with high tidal volumes attenuates myocardial dysfunction by decreasing cardiac edema in a rat model of LPS-induced peritonitis. Smeding L, Plotz FB, Lamberts RR, van der Laarse WJ, Kneyber MC, Groeneveld JA. Respir Res. 2012 Mar 20;13(1):23

Ahmadi O, Saxena P, Wilson BKJ, Bunton RW. First rib fracture and Horner's syndrome: a rare clinical entity. Ann Thorac Surg, 2012, in press

Saxena P, Abu Hasan F, Merry C. Spinal cord ischemia following coronary artery bypass surgery. J Cardiac Surg. 2012; 27(1): 45-6

Saxena P, Chai P, Galvin IF. Composite coronary venous grafts: construction made simple. Ann Thorac Surg. 2012; 93(4): 1324-5

Sjoeholm A, Saxena P, Bunton RW. Combined thyroidectomy and cardiac surgery. J Cardiac Surg. 2012; 27(3): 342-4


Wheatley CM, Baldi JC, Cassuto NA, Foxx-Lupo WT, Snyder EM. Glycemic control influences lung membrane diffusion and oxygen saturation in exercise-trained subjects with type 1 diabetes. European Journal of Applied Physiology. 111:567-578, 2011.

Hopkins SA, Baldi JC, Cutfield WS, McCowan L, Hofman PL. Effects of exercise training on maternal hormonal changes in pregnancy. Clinical Endocrinology 74:495-500, 2011.

Coffey S, Williams MJA. Quetiapine-associated cardiomyopathy. New Zealand Medical Journal 2011;124:4744

Erickson JR, Patel R, Ferguson A, Bossuyt J, Bers DM. FRET-based sensor Camui provides new insight into mechanisms of CaMKII activation in intact cardiomyocytes. Circulation Research. (2011) Sep 16;109(7):729-38.

Erickson JR, He B, Grumbach I, Anderson ME. CaMKII in the Cardiovascular System: Sensing Redox States. Physiological Reviews. (2011) Jul;91(3):889-915.

Beca S, Helli PB, Simpson JA, Zhao D, Farman GP, Jones PP, Tian X, Wilson LS, Ahmad F, Chen SR, Movsesian MA, Manganiello V, Maurice DH, Conti M, Backx PH. (2011) Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca2+ Release and Cardiac Contractility, Independently of L-Type Ca2+ Current. Circ. Res., 109(9):1024-30

Zhou Q, Xiao J, Jiang J, Wang R, Vembaiyan V, Wang A, Smith CD, Xie C, Chen W, Zhang J, Tian X, Jones PP, Zhong X, Guo A, Chen H, Zhang L, Zhu W, Yang D, Li X, Chen J, Gillis AM, Duff HJ, Cheng H, Feldman AM, Song L-S, Fill M, Back TG & Chen SRW. (2011) Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat. Med. 17:1003-1009

Wang, R., Zhong, X., Meng, X., Koop, A., Tian, X., Jones, P.P., Fruen, B.R., Wagenknecht, T., Liu, Z., & Chen, S.R.W. (2011). Localization of the dantrolene binding sequence near the FKBP binding site in the three-dimensional structure of the ryanodine receptor. Journal of Biological Chemistry, in press

Katare R, Caporali A, Zentilin L, Avolio E, Sala-Newby G, Oikawa A, Cesselli D, Beltrami AP, Giacca M, Emanueli C, Madeddu P. Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circ Res. 2011 May 13;108(10):1238-1251

Katare R, Riu F, Mitchell K, Gubernator M, Campagnolo P, Cui Y, Fortunato O, Avolio E, Cesselli D, Beltrami AP, Angelini G, Emanueli C, Madeddu P. Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132. Circulation Research, 2011;109(8): 894-906

Early Myocardial Dysfunction is not Caused by Mitochondrial Abnormalities in a Rat Model of Peritonitis. Smeding L, van der Laarse WJ, van Veelen TA, Lamberts RR, Niessen HWM, Kneyber MCJ, Groeneveld ABJ, Plötz FB. Journal of Surgical Research. 2011. DOI: 10.1016/j.jss.2011.05.055, 2011

Konstantinov IE, Saxena P, Keshavmurthy S, Newman MA. Salvage resection of a large chemorefractory mediastinal germ cell tumour. Asian Cardiovasc Thorac Annals. 2011; 19(2): 160-2

Saxena P, Boyle A, Shetty S, Edwards M. Left main coronary artery stenting prior to surgical repair of a type A aortic dissection. J Cardiac Surg. 2011; 26(6): 634-5

Saxena P, Marshall M, Ng L, Sinha A, Edwards M. Preoperative embolization of aberrant systemic artery in sequestration of lung. Asian Cardiovasc Thorac Ann. 2011; 19(5): 357-9

Saxena P, Shaw OM, Misso NL, Naran A, Shehatha J, Newman MA, d'Udekem Y, Thompson PJ, Konstantinov IE. Remote ischemic preconditioning stimulus decreases the expression of kinin receptors in human neutrophils. J Surg Res. 2011; 171(1): 311-6


Lalande S, Hofman PL, Baldi JC. Effect of reduced total blood volume on left ventricular volumes and kinetics in type 2 diabetes Acta Physiologica. 2010; 199:23-30

Hopkins SA, Baldi JC, Cutfield WS, McCowan L, Hofman PL. Non-weight-bearing exercise training in pregnancy reduces offspring birth size independent of changes in maternal insulin sensitivity. Journal of Clinical Endocrinology and Metabolism 95:2080-2088, 2010.

Baldi JC, Hofman PL. Does careful glycemic control improve aerobic capacity in type 1 diabetic subjects? Exercise and Sport Science Reviews. 38:161-167, 2010.

Baldi JC, Cassuto NA, Foxx-Lupo WT, Wheatley CM, Snyder EM. Glycemic control improves cardiopulmonary exercise response in highly trained type 1 diabetic subjects. Medicine & Science in Sports and Exercise. 42:1448-1453, 2010.

Mufti RE, Brett SE, Tran CHT, El-Rahman RA, Anfinogenova Y, El-Yazbi A, Cole WC, Jones PP, Chen SRW, & Welsh DG. (2010) Intravascular pressure augments cerebral arterial constriction by inducing voltage-insensitive Ca2+ waves. J Physiol, 588.20:3983-4005

Jiang D, Jones PP, Davis DR, Gow R, Green MS, Birnie DH, Chen SR and Gollob MH (2010) Characterization of a Novel Mutation in the Cardiac Ryanodine Receptor that Results in Catecholaminergic Polymorphic Ventricular Tachycardia. Channels. 4(4):

Siragusa M,Katare R, Meloni M, Hirsch E, Emanueli C, Madeddu P. Genetic and Pharmacological Targeting of Phosphoinositide 3-Kinaseg Impairs Angiogenesis and Healing of Experimental Myocardial Infarction in Mice. Circulation Research, 2010 Mar 5;106(4):757-68

Katare R, Caporali A, Oikawa A, Meloni M, Emanueli C, Madeddu P. Vitamin B1 Analogue Benfotiamine Prevents Diabetes-Induced Diastolic Dysfunction and Heart Failure through Akt/Pim-1 Mediated Survival Pathway. Circulation:Heart Failure, 2010, 294-305

Katare R, Ando M, Kakinuma Y, Sato T. Engineered heart tissue: a novel tool to study the ischemic changes of the heart in vitro. PLoS One. 2010 Feb 17;5(2):e9275

Campagnolo P, Cesselli D, Zen AA, Beltrami AP, Kränkel N, Katare R, Angelini GD, Emanueli C, and Madeddu P. The human adult vena saphena contains perivascular progenitor cells endowed with clonogenic and pro-angiogenic potential. Circulation, 2010, 121(15):1735-45

Katare R, Ando M, Kakinuma Y, Arikawa M, Yamasaki F, Sato T. Differential Regulation of TNF Receptors by Vagal Nerve Stimulation Protect Heart against Acute Ischemic Injury Journal of Molecular and Cellular Cardiology, 2010; 49(2):234-244

Katare R, Caporali A, Emanueli C, Madeddu P. Benfotiamine improves functional recovery of the infarcted heart via activation of pro-survival G6PD/Akt signaling pathway and modulation of neurohormonal response. Journal of Molecular and Cellular Cardiology, 2010; 49(4):625-638

Effect of bupivacaine on sevoflurane-induced cardioprotection after ischemia-reperfusion in isolated rat hearts. Bouwman RA, Vreden MJA, Wassenaar LEJ, den Oudsten GG, Loer SA, Stienen GJM, Lamberts RR. European Journal of Pharmacology. 2010. 647(1-3): 132-138

Altered jugular vein and ductus venosus flow velocities in fetuses with increased nuchal translucency and distended jugular lymphatic sacs. de Mooij YM, Bartelings MM, Twisk JW, Lamberts RR, Gittenberger-de Groot AC, van Vugt JM, Bekker MN. Am J Obstet Gynecol. 2010. 202(6):566.e1-8

Konstantinov IE, d'Udekem Y, Saxena P. Interposition pericardial flap after slide tracheoplasty in pulmonary artery sling complex. Ann Thorac Surg. 2010; 89(1): 289-91

Konstantinov IE, Saxena P. Independent lung ventilation in the postoperative management of large bronchopleural fistula. J Thorac Cardiovasc Surg. 2010; 139(2): e21-2

Konstantinov IE, Saxena P. Valve-sparing aortic root replacement and tricuspidization in a patient with an asymmentric bicuspid aortic valve. Tex Heart Inst J. 2010; 37(1): 79-81

Oka N, Liava'a M, Saxena P, d'Udekem Y, Konstantinov IE. Extended three- patch technique for congenital supravalvular stenosis. Asian Cardiovasc Thorac Ann. 2010; 18(3): 297-8

Saxena P, Downie S, Amanuel B, Newman MA, Konstantinov IE. Giant pulmonary hamartoma: an interesting clinical entity. Heart Lung Circ. 2010; 19(9): 573

Saxena P, Newman MA, Shehatha JS, Redington AN, Konstantinov IE. Remote ischemic preconditioning: evolution of the concept, mechanisms and clinical application. J Cardiac Surg. 2010; 25(1): 127-34

Saxena P, Shehatha J, Konstantinov IE. Coronary artery bypass surgery in a patient with single anomalous right coronary artery. Asian Cardiovasc Thorac Annals. 2010; 18: 577-8

Saxena P, Shehatha J, Naran A, Rajaratnam S, Newman MA, Konstantinov IE. Papillary fibroelastoma of the interventricular septum mimicking a cardiac myxoma. Tex Heart Inst J. 2010; 37(1): 119-20

Saxena P, Thompson P, d'Udekem Y, Konstantinov IE. Kallikrein-kinin system: a surgical perspective in post-aprotinin era. J Surg Res. 2010; 167(1):70-7

Shimizu M, Saxena P, Konstantinov IE, Cherepanov V, Cheung MM, Wearden P, Zhangdong H, Schmidt M, Downey GP, Redington A. Remote ischemic preconditioning decreases adhesion and selectively modifies responses of human neutrophils. J Surg Res. 2010; 158(1): 155-61

Schwenke, D.O., Pearson, J.T. K. Kangawa, K., Cragg, P.A., & Shirai, M. (2010) Exogenous ghrelin accentuates the acute hypoxic ventilatory response after 2 weeks of chronic hypoxia in conscious rats. Acta Physiol, in press.


Katare R, Kakinuma Y, Ando M, Arikawa M, Yamasaki F, Sato T. Chronic Intermittent Fasting Improves the Survival Following Large Myocardial Ischemia by Activation of BDNF/VEGF/PI3K Signaling Pathway. Journal of Molecular and Cellular Cardiology, 2009; 46:405-412

Handa T, Katare R, Sasaguri S, Sato T. Preliminary experience for the evaluation of the intraoperative graft patency with real color charge-coupled device camera system: an advanced device for simultaneous capturing of color and near-infrared images during coronary artery bypass graft. Interact Cardiovasc Thorac Surg. 2009 Aug;9(2):150-154

Reactive oxygen species-induced stimulation of 5'AMP-activated protein kinase mediates sevoflurane-induced cardioprotection. Lamberts RR, Onderwater G, Hamdani N, Vreden MJ, Steenhuisen J, Eringa EC, Loer SA, Stienen GJ, Bouwman RA. Circulation. 2009. 120(11 Suppl):S10-5

Right ventricular pacing improves right heart function in experimental pulmonary arterial hypertension: a study in the isolated heart. Handoko ML, Lamberts RR, Redout EM, de Man FS, Boer C, Simonides WS, Paulus WJ, Westerhof N, Allaart CP, Vonk-Noordegraaf A. Am J Physiol Heart Circ Physiol. 2009. 297(5):H1752-9

Konstantinov IE, Saxena P, Shehatha J. Spontaneous multivessel coronary artery dissection: surgical management in a postmenopausal woman. Tex Heart Inst J. 2009; 36(4): 360-1

Konstantinov IE, Saxena P, Barrett T, Jenkins G. Resection and reconstruction of the roof of the coronary sinus for an unusually attached left atrial myxoma. J Thorac Cardiovasc Surg. 2009; 137(4): 1032-4

Konstantinov IE, Saxena P, d'Udekem, Y, Brizard CP. Isolated subclavian artery: anatomical and surgical Considerations. Ann Thorac Surg. 2009; 88(5): 1685-7

Konstantinov IE, Saxena P, Ling S, Barrett T. Repair of acute postinfarction atrioventricular dehiscence in a patient with posterior left ventricular aneurysm. J Thorac Cardiovasc Surg. 2009; 137(1): 247-9

Konstantinov IE, Saxena P, Shehatha J. Coronary stent disease: when will enough be enough? J Thorac Cardiovasc Surg. 2009; 137(4): 1020-1

Konstantinov IE, Saxena P, Wood DJ. Stabilization of chronic flail chest: A novel approach of surgical fixation and osteogenesis. Thorax. 2009; 64: 265-6

Konstantinov IE, Saxena P. Sternal stabilization by interlocking wires: an alternative simple technique for high-risk patients. J Cardiac Surg. 2009; 24(5): 510-1

Saxena P, Bala A, Campbell K, Meloni B, d'Udekem Y, Konstantinov IE. Does remote ischemic preconditioning prevent delayed hippocampal neuronal death following transient global cerebral ischemia in rats? Perfusion. 2009; 24(3): 207-11

Saxena P, Boyt A, Newman MA. Mitral valve leaflet abscess complicating infective endocarditis. Heart Lung Circ. 2009; 18(2): 161-2

Saxena P, Friedrich L, Driesen RV, Newman MA. Value of multislice CT scan in redo cardiac surgery with previous LITA graft. Heart Lung Circ. 2009; 18(2): 159-60

Saxena P, Konstantinov IE, Downie S, Newman MA. Quadricuspid aortic valve: a rare clinical entity. Heart Lung Circ. 2009; 18(1): 50-1

Saxena P, Konstantinov IE. Bhagavant Kalke and his pioneering work on the bi- leaflet heart valve prosthesis. Ann Thorac Surg. 2009; 88(1): 344-7

Saxena P, Shehatha J, Boyt A, Newman M, Konstantinov IE. Role of extracorporeal circulation in the management of accidental deep hypothermia. Heart Lung Circ. 2009; 18(6): 416-8

Saxena P, Shehatha J, Downie S, Newman MA, Konstantinov IE. Translocation of prosthetic aortic valve in advanced prosthetic valve endocarditis. Tex Heart Inst J. 2009; 36(6): 604-6

Saxena P, Sivapathasingam V, Vicaretti M, Costa RJ. Thoracic aortic aneurysm in the presence of mediastinal and retroperitoneal fibrosis. Heart Lung Circ. 2009; 18(4): 294-5

Shehatha J, Saxena P, Clarke B, Dunning J, Konstantinov IE. Surgical management of extensive pulmonary artery sarcoma. Ann Thorac Surg. 2009; 87(4): 1269-71

Shehatha, J, Alward M, Saxena P, Konstantinov IE. Surgical management of cardiac hydatidosis. Tex Heart Inst J. 2009; 36(1): 72-3

Kishimoto, I., Tokudome, T., Schwenke, D.O., Takeshi, S., Hosoda, H., Nagaya, N., & Kangawa, K. (2009). Therapeutic potential of ghrelin in cardiac disease. Expert Review of Endocrinology and Metabolism, 4(3): 283-289.

Schwenke, D.O., Pearson, J.T., Shimochi, A., Kangawa, K., Tsuchimochi, H., Umetani, K., Shirai, M., & Cragg, P.A. (2009). Changes in pulmonary blood flow distribution in monocrotaline - compared with hypoxia-induced models of pulmonary hypertension - assessed using syncrotron radiation. Journal of Hypertension, 27(7): 1404-1409.

Shirai, M., Schwenke, D.O., Eppel, G.A., Evans, R.G., Edgley, A.J., Tsuchimochi, H., Umentani, K and Pearson, J.T. (2009). Synchrotron based angiography for investigating regulation of vasomotor function in the microcirculation in vivo. Clin Exp Pharmacol Physiol, Jan;36(1):107-16.


Erickson JR, Anderson ME. CaMKII and its role in cardiac arrhythmia. Journal of Cardiovascular Electrophysiology. (2008) Dec;19(12):1332-6.

Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, O\'Donnell SE, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham AJ, Weiss RM, Spitz DR, Shea MA, Colbran RJ, Mohler PJ, Anderson ME. A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell. (2008) 133(3): 462-74.

Kong H, Jones PP, Koop A, Zhang L, Duff HJ, Chen SR (2008) Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor. Biochem. J. 414:441-452

Jiang D, Chen W, Xiao J, Wang R, Kong H, Jones PP, Zhang L, Fruen B, Chen SR (2008) Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia. J. Biol. Chem. 283(30):20813-20820

Jones PP, Jiang D, Bolstad J, Hunt DJ, Zhang L, Demaurex N, Chen SR (2008) Endoplasmic reticulum Ca2+ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release. Biochem. J. 412:171-178

Kakinuma Y, Katare R, Arikawa M, Muramoto K, Yamasaki F, Sato T. A HIF-1alpha-related gene involved in cell protection from hypoxia by suppression of mitochondrial function FEBS Lett, 2008; 582(2):332-340

Konstantinov IE, Saxena P, Blackham R, Barrett T, Finn C, Newman MA. Thrombus straddling an atrial septal defect: surgical prevention of massive pulmonary and systemic embolization. Tex Heart Inst J. 2008; 35(4): 475-6

Konstantinov IE, Saxena P, Shehatha J, Mitchell A, Cherian S. Novel aeration technique for necrotizing fasciitis of the chest wall. Ann Thorac Surg. 2008; 86(8): 1973-4

Konstantinov IE, Saxena P, vanden Dreisen R, Newman MA. Large bronchogenic cyst: diagnosis and surgical management. Heart Lung Circ. 2008; 17(2): 146-8

Messer S, Saxena P, Mickelburgh M, Jalali H, Konstantinov IE. Mitral valve replacement in calcified annulus following ring annuloplasty. Asian Cardiovasc Thorac Ann. 2008; 16(6): 488-9

Newman MA, Saxena P, Luthra S, Konstantinov IE. "Gumnut device" for off-pump proximal aortocoronay anastomosis. J Cardiac Surg. 2008; 23(5): 511-2

Saxena P, Konstantinov IE, Newman MA, Luthra S. In defense of aortocoronary top-end markers. J Card Surg. 2008; 23(4): 411-2

Saxena P, Konstantinov IE, Stewart N, Newman MAJ. Palliative surgical management of iatrogenic oesophageal perforation in the setting of malignant disease. Heart Lung Circ. 2008; 17(5): 434-6

Saxena P, Konstantinov IE, Zelei D, Newman MA. Spontaneous subscapular abscess: a rare surgical condition. Heart Lung Circ. 2008; 17(6): 517-8

Saxena P, Lee A, Konstantinov IE, Newman MA. Papillary fibroelastoma of aortic valve: diagnosis and surgical management. Heart Lung Circ. 2008; 17(4): 349-51

Saxena P, Zelei D, Friederich L, Naran A, Newman MA. Recurrent bilateral pneumothoraces associated with metastatic synovial sarcoma. Heart Lung Circ. 2008; 17(3): 241-2

Schwenke, D.O., Tokudome, T., Kishimoto, I., Horio, T., Shirai, M., Cragg, P. A., Kangawa, K. (2008). Early ghrelin treatment following myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality. Endocrinology 149(10):5172-6.

Tokudome, .T, Kishimoto, I., Horio, T., Arai, Y., Schwenke, D.O., Hino, J., Okano, I., Kawano, Y., Kohno, M., Miyazato, M., Nakao, K., Kangawa, K. (2008). Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart. Circulation 6;117(18):2329-39.

Soeki, T., Kishimoto, I., Schwenke, D.O., Tokudome, T., Horio, T., Yoshida, M., Hosoda, H., Kangawa, K. (2008). Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction. Am J Physiol Heart Circ Physiol. Jan;294(1):H426-32.

Schwenke, D.O., Pearson, J.T., Kangawa, K., Umetani, K., Shirai, M. (2008). Changes in macrovessel pulmonary blood flow distribution following chronic hypoxia - assessed using synchrotron radiation microangiography. J Appl Physiol. Jan;104(1):88-96.

Schwenke, D.O., Tokudome, T., Shirai, M., Hosoda, H., Horio, T., Kishimoto, I., Kangawa, K. (2008). Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats. Endocrinology. Jan;149(1):237-44.


Jones PP, Meng X, Xiao B, Cai S, Bolstad J, Wagenknecht T, Liu Z, and Chen SR (2007) Localization of PKA Phosphorylation Site, Serine-2030, in the Three-Dimensional Structure of Cardiac Ryanodine Receptor. Biochem. J. 410(2):261-70

Xiao J, Tian X, Jones PP, Bolstad J, Kong H, Wang R, Zhang L, Duff HJ, Gillis AM, Kotlikoff M, Copello JA, and Chen SR (2007) Removal of FKBP12.6 Does not Alter the Conductance and Activation of Cardiac Ryanodine Receptor and the Susceptibility to Stress-induced Ventricular Arrhythmias. J. Biol. Chem. 282(48):34828-38

Xiao B, Tian X, Xie W, Jones PP, Cai S, Wang X, Jiang D, Kong H, Zhang L, Chen K, Walsh MP, Cheng H, and Chen SR (2007) Functional consequence of PKA-dependent phosphorylation of the cardiac ryanodine receptor: Sensitization of store-overload-induced Ca2+ release (SOICR). J. Biol. Chem. 282(41):30256-64

Hunt DJ*, Jones PP*, Wang R, Chen W, Bolstad J, Chen K, Shimoni Y, Chen SR (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem. J. 404(3):431-8. (*Co-first authors)

Katare R, Zhitian Z, Sodeoka M, Sasaguri S. A Novel Bisindolylmaleimide Derivative Enhances Functional Recovery of Heart following Long-term Hypothermic Heart Preservation. Transplantation 83(12):1588-1594, 2007

Sevoflurane-induced cardioprotection depends on PKC-alpha activation via production of reactive oxygen species. Bouwman RA, Musters RJ, van Beek-Harmsen BJ, de Lange JJ, Lamberts RR, Loer SA, Boer C. Br J Anaesth. 2007. 99(5):639-45

Preservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats. Lamberts RR, Caldenhoven E, Lansink M, Witte G, Vaessen RJ, St Cyr JA, Stienen GJ. Am J Physiol Heart Circ Physiol. 2007. 293(3):H1869-76

Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium. Lamberts RR, Hamdani N, Soekhoe TW, Boontje NM, Zaremba R, Walker LA, de Tombe PP, van der Velden J, Stienen GJ. J Physiol. 2007. 582(Pt 2):695-709

Right ventricular hypertrophy causes impairment of left ventricular diastolic function in the rat. Lamberts RR, Vaessen RJ, Westerhof N, Stienen GJ. Basic Res Cardiol. 2007. 102(1):19-27

Konstantinov IE, Newman MAJ, Saxena P. Monaldi's intracavitary decompression and its modifications (Reply). Ann Thorac Surg. 2007; 84: 1075

Konstantinov IE, Saxena P, Friederich L, Newman MAJ. Emergency surgery following failed device closure of the atrial septal defect. J Thorac Cardiovasc Surg. 2007; 133(3): 849-50

Konstantinov IE, Saxena P, Koniuszko M, Alvarez JM, Newman MA. Iatrogenic esophageal perforation with necrotizing mediastinitis: surgical management following delayed presentation. ANZ J Surg. 2007; 77(5): 399-401

Konstantinov IE, Saxena P, Koniuszko M, Ghosh S, Low VH, Khor TS, Naran A, Newman MA. Superior vena cava obstruction by tumour thrombus in invasive thymoma: diagnosis and surgical management. Heart Lung Circ. 2007; 16(6): 462-4

Konstantinov IE, Saxena P, Koniuszko MD, Alvarez J, Newman MA. Acute massive pulmonary embolism with cardiopulmonary resuscitation: management and results. Tex Heart Inst J. 2007; 34(1): 41-5

Saxena P, Clarke B, Dunning J. Aspergillus endocarditis of the mitral valve in a lung-transplant patient. Tex Heart Inst J. 2007; 34(1): 95-73

Saxena P, Kejriwal N, Newman MA. Use of flexible silastic drains in thoracic surgery: a word of caution. Ann Thorac Surg. 2007; 83(6): 2258-9

Saxena P, Konstantinov IE, Lee A, Newman MA. Papillary fibroelastoma of aortic valve: early diagnosis and surgical management. J Thorac Cardiovasc Surg. 2007; 133(3): 849-50

Saxena P, Konstantinov IE, Newman MA. Severe vasospasm in off-pump coronary artery bypass surgery: a difficult clinical problem. J Thorac Cardiovasc Surg. 2007; 134(5): 1380-1

Saxena P, Konstantinov IE, Newman MA. Use of temporary epicardial pacing wires in cardiac surgery. Heart Lung Circ. 2007; 16(1): 60

Saxena P, Luthra S, Dhaliwal RS, Singh RS, Behera D. Early changes in pulmonary functions after mitral valve replacement. Ann Thorac Med. 2007; 2(3): 111-7

Saxena P, Tam R. Papaverine hydrodissection of internal thoracic artery. Asian Cardiovasc Thorac Ann. 2007; 15(6): 542

Saxena P, Tesar PJ. Vascular obstruction related to mediastinal fibrosis: an interesting clinical entity. J Thorac Cardiovasc Surg. 2007; 134(5): 1379

Pearson, J.T., Shirai, M., Tsuchimoch,i H., Schwenke, D.O., Takayuki, I., Kangawa, K., Suga, H., Yagi, N. (2007). Effects of sustained length-dependent activation on in situ cross-bridge dynamics in rat hearts. Biophys J. Dec 15;93(12):4319-29.

Schwenke, D.O., Pearson, J.T., Kangawa, K., Umetani, K., Shirai, M. (2007). Imaging of the pulmonary circulation in the closed-chest rat using synchrotron radiation microangiography. J Appl Physiol 102: 787-793.

Schwenke, D.O., Bolter, C.P., Cragg, P.A. (2007). Are the carotid bodies of the guinea-pig functional? Comp Biochem Physiol A Mol Integr Physiol. Feb;146(2):180-8.

Pearson, J.T., Shirai, M., Yokoyama, C., Tsuchimochi, H., Schwenk ,D.O., Shimouchi, A., Kangawa, K., Tanabe, T. (2007). alpha(2)-Adrenoreceptor mediated sympathoinhibition of heart rate during acute hypoxia is diminished in conscious prostacyclin synthase deficient mice. Pflugers Arch. Apr;454(1):29-39.

Schwenke, D.O., Pearson, J.T., Tsuchimochi, H., Kangawa, K., Shirai, M. (2007). Pulmonary vascular reactivity of spontaneously hypertensive rats is exacerbated in response to the central administration of exogenous nitric oxide? Clin Exp Pharmacol Physiol. Jan-Feb;34(1-2):88-94.


Erickson JR, Moerland TS. Functional characterization of parvalbumin from the Arctic cod (Boreogadus saida): similarity in calcium affinity among parvalbumins from polar teleosts. Journal of Comparative Biochemistry and Physiology: Part A. (2006) 143(2): 228-233.

Jones PP, Bazzazi H, Kargacin GJ and Colyer J (2006) Inhibition of cAMP-dependent protein kinase under conditions occurring in the cardiac dyad during a Ca2+ transient. Biophys. J. 15; 91(2):433-43

Kuwabara M, Kakinuma Y, Ando M, Katare RG, Yamasaki F, Doi Y, Sato T. Nitric Oxide Stimulates Vascular Endothelial Growth Factor Production in Cardiomyocytes involved in angiogenesis. The Journal of Physiological Sciences 56(1):95-101, 2006

Cross-talk between cardiac muscle and coronary vasculature. Westerhof N, Boer C, Lamberts RR, Sipkema P. Physiol Rev. 2006. 86(4):1263-308. Review

Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium. van der Velden J, Narolska NA, Lamberts RR, Boontje NM, Borbély A, Zaremba R, Bronzwaer JG, Papp Z, Jaquet K, Paulus WJ, Stienen GJ. Cardiovasc Res. 2006. 69(4):876-87

Schwenke, D.O., Pearson, J.T., Mori, H., Shirai, M. (2006). Does central nitric oxide elicit pulmonary hypertension in conscious rats? Respir Physiol Neurobiol, 153(3):250-60.

Schwenke, D.O., Pearson, J.T., Kangawa, K., Shirai, M. (2006). Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats? Acta Physiol. 186(4), 309-318.

Schwenke, D.O., Pearson, J.T., Mori, H., & Shirai, M. (2006). Long-term monitoring of pulmonary arterial pressure in conscious, unrestrained mice. J Pharmacol Toxicol Methods 53(3):277-283.

Eppel, G.A., Schwenke, D.O., Evans, R.G., Edgley, A.J., Brown, R., Umetani, K., Shirai, M., Pearson, J.T. (2006). Application of Synchrotron micro-angiography to studies of blood flow regulation in small animal models: current status. Hypertension abstracts 2006 HBPRCA.


Erickson JR, Moerland TS. A competition assay of magnesium affinity for EF-hand proteins based on the fluorescent indicator magnesium green. Analytical Biochemistry. (2005) 345(2): 343-5.

Erickson JR, Sidell B, Moerland TR. Temperature sensitivity of calcium binding for parvalbumins from Antarctic and temperate zone teleost fishes. Journal of Comparative Biochemistry and Physiology: Part A. (2005) 140: 179-185.


Katare RG, Sasaguri S, Suzuki R, Maeda H. Ischemic Preconditioning Prevents Reperfusion Heart Injury in Cardiac Hypertrophy by Activation of Mitochondrial KATP Channels. International Journal of Cardiology. 96(1): 41-49. 2004


Katare RG, Sasaguri S, Zhitian Z, Suzuki R, Asakai R, and Maeda H. Second window of ischemic preconditioning regulates mitochondrial permeability transition pore by enhancing Bcl-2 expression, Cardiovascular Research, 59(2): 297-307, August 1, 2003

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University of Otago Research GrantOtago Medical Research FoundationMarsden FundLottery Health ResearchHeart FoundationHealthcare Otago TrustHealth Research Council